Fig. 1: Age-dependent transgenic APP/Aβ overloading in L5 neurons in PFC and VC. | Translational Psychiatry

Fig. 1: Age-dependent transgenic APP/Aβ overloading in L5 neurons in PFC and VC.

From: Early impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer’s disease mouse model

Fig. 1

A Immunohistochemistry staining for APP/Aβ using the 6E10 antibody. L5 neurons show immunoreactivity of APP/Aβ in prefrontal cortex at P22, with much stronger labeling at P42. B Intraneuronal APP/Aβ immunoreactivity was significantly stronger in P42 compared to that from P22 (t10 = 6.35, n = 6 mice/group, ****p < 0.0001). C APP/Aβ immunolabeling in L5 pyramidal neurons in the primary visual cortex (V1) at P28 and P56. D Quantification of APP/Aβ signals show a significant increase in V1-L5 neurons at P56 (t10 = 6.67, n = 6 mice/group, ****p < 0.0001).

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