Fig. 4: 5XFAD VC-L5 neurons show reduced spontaneous synaptic mEPSC and mIPSC inputs during critical period (P28–32). | Translational Psychiatry

Fig. 4: 5XFAD VC-L5 neurons show reduced spontaneous synaptic mEPSC and mIPSC inputs during critical period (P28–32).

From: Early impairment of cortical circuit plasticity and connectivity in the 5XFAD Alzheimer’s disease mouse model

Fig. 4

A Representative whole cell patch clamp recording (5-sec traces) of spontaneous mEPSC from 5XFAD and WT neurons. Vertical ticks indicate time stamps for detected mEPSCs. B A larger percentage of mEPSC amplitudes from 5XFAD neurons distributes to the smaller amplitude bins. There was significant difference between the two cumulative distribution curves (K-S test, D = 0.204, ***P < 0.001). C Violin plot of all mEPSC amplitudes from both groups. D 5XFAD VC-L5 neurons did not differ in mEPSC frequency (WT, n = 11 cells/6 mice; 5XFAD, n = 13 cells/7 mice. p = 0.27). E Representative traces of spontaneous mIPSCs (4-sec traces) from 5XFAD and WT neurons. F A larger fraction of mIPSC amplitudes from 5XFAD neurons also distributed to the lower amplitude bin, with a significant difference in the cumulative distribution curves (K-S test, D = 0.124, ****p < 0.0001). G Violin plot of all analyzed mIPSC amplitudes from both groups. H 5XFAD neurons showed similar mIPSC frequency (WT, n = 9 cells/6 mice; 5XFAD, n = 11 cells/7 mice. p = 0.30).

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