Fig. 3: Oxytocin and orexin agents do not alter heroin choice. | Translational Psychiatry

Fig. 3: Oxytocin and orexin agents do not alter heroin choice.

From: Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

Fig. 3

Neither the low dose (1 mg/kg) or the high dose (3 mg/kg) of oxytocin altered heroin choice (a, left), or lever presses for heroin (a, middle) or food (a, right). The oxytocin antagonist, L-368,899 (5 mg/kg), did not alter choice (b, left), lever presses for heroin (b, middle) or food (b, right). The dual orexin receptor antagonist DORA-12 did not alter heroin choice (c, left), lever presses for heroin (c, middle) or food (c, right), at either the low (10 mg/kg) or high dose (30 mg/kg). Data shown as mean ± SEM.

Back to article page