Table 1 The top ten significantly associated genes observed in the schizophrenia and substance dependence (AD, CUD, ND, and OD) MAGMA meta-analyses that were nominally significant (P < 0.05) in the individual GWAS but did not pass multiple-testing corrections.

From: Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance

Gene symbol

PSZ

PSUD

PMETA

MED27

6.47 × 10−5

ND, 1.425 × 10−5

SZ + ND, 8.64 × 10−9

BDNF

4.22 × 10−6

AD, 1.08 × 10−2

SZ + AD, 2.75 × 10−7

CUD, 1.39 × 10−4

SZ + CUD, 3.42 × 10−8

IZUMO1

2.29 × 10−5

AD, 6.52 × 10−3

SZ + AD, 1.05 × 10−6

CUD, 1.13 × 10−4

SZ + CUD, 7.67 × 10−8

HYAL3

2.06 × 10−5

CUD, 1.47 × 10−4

SZ + CUD, 9.83 × 10−8

HMGN4

3.65 × 10−4

CUD, 2.63 × 10−5

SZ + CUD, 1.00 × 10−7

EP300

1.18 × 10−5

AD, 9.72 × 10−4

SZ + AD, 1.36 × 10−7

SPECC1

8.28 × 10−6

AD, 1.99 × 10−3

SZ + AD, 1.51 × 10−7

PPP2R2A

2.95 × 10−6

OD, 9.82 × 10−3

SZ + OD, 1.78 × 10−7

MED19

1.16 × 10−5

AD, 2.82 × 10−2

SZ + AD, 1.74 × 10−6

CUD, 3.53 × 10−4

SZ + CUD, 2.01 × 10−7

OD, 3.25 × 10−2

SZ + OD,, 1.99 × 10−6

FUT2

3.37 × 10−6

AD, 1.02 × 10−2

SZ + AD, 2.10 × 10−7

CUD, 4.18 × 10−3

SZ + CUD, 2.55 × 10−6

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