Table 3 Significant CpG sites (ACME P and TE P < 0.05) resulting from HDMA and CMA of DNAm as a potential mediator of the association between PAE and neurodevelopmental delay at 6 months of age using the DACT method and after correction for multiple testing (BH FDR ≤0.05). ACME, ADE, TE, PM and corresponding 95% confidence intervals estimated by CMA are shown.

From: DNA methylation as a potential mediator of the association between prenatal tobacco and alcohol exposure and child neurodevelopment in a South African birth cohort

Domain

CpG (Gene)

ACME (95% CI)

ADE (95% CI)

Total effect (95% CI)

Prop med. (95% CI)

Motor (n = 110)

cg00086871 (TBC1D14)

−1.8 (−4.4, −0.07)

−8.1 (−15.4, −0.83)

−9.9 (−17.1, −2.9)

0.18 (4.6e-03, 0.69)

cg00512279 (SLC18A2)

−2.5 (−6.1, −0.21)

−7.3 (−14.5, 0.46)

−9.8 (−16.7, −2.9)

0.25 (0.02, 1.1)

cg02230180 (HNRNPU)

−2.6 (−6.1, −0.14)

−7.4 (−14.8, 0.49)

−10.0 (−16.8, −2.9)

0.26 (0.02, 1.1)

cg03113572 (ZNF331)

−3.5 (−7.4, −0.59)

−5.9 (−12.7, 1.0)

−9.3 (−16.5, −2.2)

0.37 (0.06, 1.3)

cg04743947

−2.7 (−6.7, −0.03)

−6.7 (−14.3, 0.85)

−9.4 (−16.5, −2.6)

0.29 (2.8e-03, 1.2)

cg04875987 (LRRC45, STRA13)

−3.0 (−6.9, −0.29)

−6.3 (−13.5, 1.1)

−9.2 (−16.2, −2.2)

0.32 (0.03, 1.2)

cg05141711 (AGMAT)

−2.8 (−6.7, −0.28)

−6.9 (−13.7, −0.11)

−9.7 (−16.5, −2.9)

0.29 (0.03, 0.9)

cg09528884 (KLLN, PTEN)

−4.0 (−8.2, −1.30)

−6.7 (−13.5, 5.3e-03)

−10.6 (−17.7, −3.8)

0.37 (0.13, 0.97)

cg10137084 (CACNA2D3)

−3.3 (−7.9, −0.13)

−6.6 (−13.2, 0.99)

−9.8 (−16.5, −2.8)

0.33 (5.6e-03, 1.3)

cg12653570

−2.7 (−6.5, −0.19)

−7.1 (−13.5, −0.49)

−9.8 (−16.9, −2.9)

0.27 (0.02, 0.78)

cg12789343

−2.0 (−4.8, −0.04)

−8.0 (−15.1, −1.2)

−10.0 (−16.8, −3.1)

0.20 (5.9e-03, 0.64)

cg19340420 (RCN3)

−2.9 (−6.1, −0.49)

−7.4 (−14.8, −0.64)

−10.3 (−17.1, −3.3)

0.28 (0.05, 0.86)

cg22804663 (TDG)

−3.0 (−6.4, −0.09)

−6.6 (−13.9, −0.04)

−9.7 (−16.9, −2.5)

0.31 (−3.1e-03, 0.96)

cg23238147 (KAZN, TMEM51-AS1)

−2.3 (−5.4, −0.11)

−6.8 (−14.0, 0.23)

−9.2 (−16.1, −2.3)

0.25 (3.0e-03, 1.0)

cg24716343 (PCNX2)

−2.8 (−6.2, −0.30)

−6.2 (−12.8, 1.20)

−9.0 (−16.0, −1.9)

0.31 (0.04, 1.3)

cg26848718 (WT1)

−3.4 (−8.3, −0.23)

−5.4 (−11.9, 1.30)

−8.8 (−15.7, −2.0)

0.39 (0.02, 1.3)

Adaptive behavior (n = 112)

cg21553656 (DAG1)

−2.1 (−4.4, −0.35)

−2.3 (−5.98, 1.90)

−4.3 (−8.2, −0.3)

0.48 (0.03, 2.0)

Back to article page