Table 3 Associations of ACE scores (Total, Maltreatment, Household Dysfunction) with Biological Aging.

From: Dimensions of childhood adversity differentially affect biological aging in major depression

 

AgeAccelPheno

AgeAccelGrim

 

b (95% CI)

β

p-value

b (95% CI)

β

p-value

Total ACE score

Model 1

0.230 [−0.336, 0.797]

0.091

0.421

0.015 [−0.088, 0.117]

0.032

0.778

Model 2

0.165 [−0.520, 0.850]

0.065

0.632

−0.020 [−0.122, 0.082]

−0.044

0.697

Maltreatment

Model 1

1.16 [0.353, 1.96]

0.307

0.005

.0005 [−0.147, 0.157]

0.008

0.944

Model 2

1.05 [0.123, 1.97]

0.277

0.027

−0.04 [−0.185, 0.099]

−0.063

0.552

Model 3a

1.21 [0.309, 2.12]

0.322

0.009

−0.044 [−0.190, 0.101]

−0.065

0.544

Household Dysfunction

Model 1

−0.820 [−1.75, 0.111]

−0.194

0.083

0.034 [−0.137, 0.204]

0.044

0.697

Model 2

−1.06 [−2.18, 0.071]

−0.249

0.066

0.005 [−0.167, 0.178]

0.007

0.95

Model 3b

−1.29 [−2.38, −0.194]

−0.304

0.022

0.014 [−0.161, 0.189]

0.018

0.875

  1. Note the opposite direction of association between epigenetic age acceleration and maltreatment or household dysfunction score.
  2. Model 1. Unadjusted model.
  3. Model 2. Adjusted for gender, BMI, smoking status, race, household income and DNAm-based markers of immune cell composition.
  4. aModel 3. Model 2 further adjusted for Household Dysfunction score.
  5. bModel 3. Model 2 further adjusted for Maltreatment score.
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