Fig. 6: Multidimensional analysis has the sensitivity to detect behavioral improvement in Ube3am-/p+ mice following treatment. | Translational Psychiatry

Fig. 6: Multidimensional analysis has the sensitivity to detect behavioral improvement in Ube3am-/p+ mice following treatment.

From: Multidimensional analysis of behavior predicts genotype with high accuracy in a mouse model of Angelman syndrome

Fig. 6

a Multidimensional analysis used 12 behavioral measures from Wolter et al. (Dataset 3). *Indicates sex difference and standardization by sex. b Animals with paternal Ube3a unsilencing (purple open circles) have a qualitatively intermediate behavioral profile between Ube3am-/p+ mutants (AS; red) and wild-type controls (WT; black). c In 1PC space, treated AS mice show overall behavioral improvement relative to control AS mice, but not full rescue. Full timeline of behavioral tests and analysis using different combinations of behavioral tests is shown in Fig. S11. Data represent mean ± SEM; ****p < 0.0001.

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