Table 2 Candidate upstream transcription factors based on DEGs associated with the Acute and Chronic Drinking groups.
Drinking groups | |||||
|---|---|---|---|---|---|
Drinking condition | Gene symbol | Gene name | Actual targets | p-val | z-score |
Acute | Taf3 | TATA-Box Binding Protein Associated Factor 3 | 2 | 1.04E−04 | 16.02 |
c-Jun | Jun Proto-Oncogene, AP-1 Transcription Factor Subunit | 7 | 2.94E−04 | 5.76 | |
c-Fos | Fos Proto-Oncogene, AP-1 Transcription Factor Subunit | 5 | 1.87E−04 | 5.27 | |
Sox17 | SRY (Sex Determining Region Y)-Box Transcription Factor 17 | 22 | 3.60E−04 | 3.63 | |
Chronic | Rbpj | Recombination Signal Binding Protein for Immunoglobulin Kappa J Region | 58 | 2.27E−11 | 7.18 |
Sox17 | SRY (Sex Determining Region Y)-Box Transcription Factor 17 | 69 | 4.86E−11 | 6.70 | |
Foxp3 | Forkhead Box P3 | 57 | 4.62E−08 | 5.69 | |
Tal1 | TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor | 61 | 9.83E−08 | 5.45 | |
Creb1 | CAMP Responsive Element Binding Protein 1 | 44 | 1.29E−07 | 5.74 | |
Ets1 | ETS Proto-Oncogene 1, Transcription Factor | 53 | 9.50E−07 | 5.09 | |
c-Myc | MYC Proto-Oncogene, BHLH Transcription Factor | 37 | 6.78E−05 | 4.22 | |
Runx1 | Runt-Related Transcription Factor 1 | 46 | 1.17E−04 | 3.94 | |
Gata-2 | GATA Binding Protein 2 | 23 | 1.63E−04 | 4.20 | |
E2f1 | E2F Transcription Factor 1 | 37 | 1.79E−04 | 3.92 | |
Zfx | Zinc Finger Protein X-Linked | 23 | 2.20E−04 | 4.10 | |
Gabp | GA Binding Protein Transcription Factor Subunit Alpha | 35 | 3.97E−04 | 3.69 | |
Cebpe | CCAAT/Enhancer Binding Protein (C/EBP), Epsilon | 4 | 6.07E−04 | 5.85 | |
Yy1 | YY1 Transcription Factor | 13 | 7.79E−04 | 3.95 | |
Ash2 | ASH2 Like, Histone Lysine Methyltransferase Complex Subunit | 21 | 2.54E−03 | 3.21 | |
Glis3 | GLIS Family Zinc Finger 3 | 20 | 2.82E−03 | 3.19 | |
Klf9 | Kruppel Like Factor 9 | 3 | 3.47E−03 | 4.93 | |
