Table 3 HD-GWAS results for the GenLang Cohort q < 0.05.

From: Hypothesis-driven genome-wide association studies provide novel insights into genetics of reading disabilities

Hypothesis

SNP

Position

Gene

P GWAS

qSFDR

Neuronal Migration/Axon Guidance

rs1168041

1:62960250

DOCK7

6.61 × 10–7

1.02 × 10–2

 

rs6089259

20:60246390

CDH4

7.03 × 10–6

1.02 × 10–2

 

rs17158413

15:83235408

CPEB1

4.42 × 10–5

2.92 × 10–2

  1. Total SNPs: 5,552,103.
  2. Upweighted SNPs: Neuronal migration 115,448.
  3. SNP Single Nucleotide Polymorphism, Position chromosome: base pair (hg19), P GWAS P-value in GWAS, qSFDR q-value from SFDR program.
  4. Additional information including LD SNPs or SNPs in same gene region, rank and up-weighted status in the supplementary material.
  5. Threshold for significance q ≤ 2.5 × 10−2.
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