Fig. 5: Overlap of differentially expressed genes with those arising from a social play study. | Translational Psychiatry

Fig. 5: Overlap of differentially expressed genes with those arising from a social play study.

From: Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes

Fig. 5

A Venn diagram detailing the significant overlap between DEGs in the Direct group (CON vs PPS) and an amygdala social play dataset detailed in Alugubelly et al. [55]. B Bar chart showing that most overlapping genes are in opposite directions in both studies. C Fold changes of both datasets are significantly negatively correlated with one another. D Heatmap showing that expression of overlapping genes are in different directions, suggesting that genes upregulated during social play in the amygdala are downregulated in the PFC of PPS rats during a social interaction. DEGs differentially expressed genes, CON control, PPS prepubertal stress.

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