Fig. 5: Short grooming bouts, head/body twitches and scratching were reduced by aripiprazole. | Translational Psychiatry

Fig. 5: Short grooming bouts, head/body twitches and scratching were reduced by aripiprazole.

From: The Sapap3−/− mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours

Fig. 5

A Acute treatment with aripiprazole (1.5 mg/kg) significantly reduced the number of single-phase grooming, head/body twitches and scratching (Wilcoxon signed-rank test: all p < 0.01; non-parametric, paired permutation test: all p < 0.01), but not the number of syntactic grooming events (Wilcoxon signed-rank test: p = 0.08 and non-parametric, paired permutation test: p = 0.09). Plotted are the proportions of number of RB events under aripiprazole treatment and the sum of the number of RB events (vehicle + aripiprazole) of individual mice. B Aripiprazole in particular shorter grooming events in Sapap3−/− mice. The x-axis is depicted on a log10 scale. Box whisker plots were designed as described in the legend of Fig. 2. Vehicle and aripiprazole conditions are colour-coded in blue and red, respectively. *p < 0.05, **p < 0.01, ns non-significant.

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