Table 2 Clinical, CSF biomarker, and genetic comparisons between subtypes.

From: Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals

 

ADNI2

ADNI1/GO/3

Subcortex-priority (n = 257)

Cortex-priority (n = 274)

F value

PFDR value

Subcortex-priority (n = 217)

Cortex-priority (n = 122)

F value

PFDR value

Clinical profiles

MMSE

28.8 ± 1.36

28.2 ± 1.76

21.57

<0.0001

28.6 ± 1.51

28.2 ± 1.65

5.64

0.0232

Memory

0.9 ± 0.68

0.4 ± 0.79

47.00

<0.0001

0.8 ± 0.68

0.6 ± 0.68

6.41

0.0177

Executive function

0.8 ± 0.90

0.4 ± 0.91

27.07

<0.0001

0.8 ± 0.85

0.5 ± 0.78

10.55

0.0029

Language function

0.7 ± 0.70

0.4 ± 0.84

23.77

<0.0001

0.6 ± 0.80

0.6 ± 0.69

0.44

0.5732

Visuospatial function

0.1 ± 0.68

0.1 ± 0.72

0.19

0.6569

0.2 ± 0.67

0.2 ± 0.65

0.01

0.9685

CSF Biomarkers

Aβ

1346.1 ± 376.26

861.4 ± 359.82

212.36

<0.0001

1319.1 ± 424.25

764.8 ± 333.06

75.11

<0.0001

t-tau

242.8 ± 104.91

290.0 ± 133.92

18.19

<0.0001

246.6 ± 94.64

299.1 ± 111.81

10.18

0.0030

p-tau

22.0 ± 10.73

28.5 ± 14.96

28.79

<0.0001

22.3 ± 10.39

30.3 ± 13.27

17.95

0.0004

Genotype

APOE ε4 (0/1/2)

182/67/8

125/117/32

38.07a

<0.0001

159/52/5

66/47/9

14.84a

0.0015

  1. Data are presented as n or mean ± SD. Tests are based on chi-square and ANOVA when appropriate.
  2. ameans χ2. MMSE Mini-Mental State Examination, CSF cerebrospinal fluid, Aβ beta-amyloid, t-tau total tau, p-tau phosphorylated tau.
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