Fig. 3: Transcriptome analysis of PD-iMGs. | Translational Psychiatry

Fig. 3: Transcriptome analysis of PD-iMGs.

From: A molecular characterization and clinical relevance of microglia-like cells derived from patients with panic disorder

Fig. 3

a Hierarchical clustering and heatmap of differentially expressed genes between HC- and PD-iMGs. Fold change >1.5, P-value <0.05. b Graphical index of the number of differentially expressed genes between HC- and PD-iMGs. c The top 10 enriched pathways are annotated among databases. Cholesterol and steroid biosynthesis pathways were highlighted in orange color. d The top four gene set enrichment plots in GSEA rank. e Core genes are enriched in the top four pathways. The overlapped genes among pathways are shown in orange color. f Unpaired t test of logarithmic normalized read count of overlapped genes between HCs and PDs. To compare statistical significance between the two groups, we conducted an unpaired t test. *P < 0.05, and **P < 0.01.

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