Fig. 6: Fluvoxamine and fluoxetine prevent memory impairment by LPS.

A The graph depicts the time that animals remained in the lit chamber on the day following conditioning during a 5 min trial. When administered 1 h prior to LPS followed by conditioning in a one-trial inhibitory avoidance task, both fluvoxamine (10 mg/kg i.p.) and fluoxetine (10 mg/kg i.p.) prevented the adverse effects of LPS on learning. When LPS (1 mg/kg i.p.) was administered 1 h following vehicle (DMSO) and 1 h prior to conditioning, rats were markedly impaired in one-trial learning. Animals receiving vehicles followed one hour later by saline (the vehicle for LPS), showed intact learning. Statistical analyses show results from Dunnett’s multiple comparison tests (***p = 0.0002; ****p < 0.0001). B Twenty-four hours after LPS, rats showed weight loss, whereas vehicle-treated controls showed weight gain. Neither fluvoxamine nor fluoxetine altered LPS-induced weight loss by Dunnett’s test (****p < 0.0001).