Fig. 2: Directed acyclic graph depicting the relationships between stress and stress-related psychopathology and GrimAA. | Translational Psychiatry

Fig. 2: Directed acyclic graph depicting the relationships between stress and stress-related psychopathology and GrimAA.

From: Associations of stress and stress-related psychiatric disorders with GrimAge acceleration: review and suggestions for future work

Fig. 2

Green lines indicate causal or mediating paths. Pink lines indicate confounding paths. Minimally sufficient adjustment set (MSAS) for direct effect of stress and stress-related psychopathology on GrimAA = Tobacco Use + Alcohol Use + BMI + Physical Activity + Medical Illness + Blood Cell Composition + Sex + Race + Adult SES. MSAS for Total Effect = Adult SES + Race + Sex. Generated with daggity.net, modified for clarity. Supplementary Materials include code to reconstruct this DAG at dagitty.net.

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