Fig. 1: Generation of a rat model of resilience and vulnerability to acute footshock stress. | Translational Psychiatry

Fig. 1: Generation of a rat model of resilience and vulnerability to acute footshock stress.

From: Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress

Fig. 1

A Experimental plan timeline. Basal (spontaneous) sucrose intake was established exposing the rats to the sucrose intake test twice a week for 4 weeks. Animals were then subjected to a single session of FS and sucrose intake test was performed again 24 h after FS. B Sucrose intake measured 24 h after FS. Mann Whitney test, *p < 0.05; N = 21 (CNT), 41 (FS). C Sucrose intake measured 24 h after FS with separation of resilient (FS-R) and vulnerable (FS-V) rats applying a 75% of sucrose intake cut-off. Kruskal-Wallis test, Dunn’s post-hoc test: ****p < 0.0001; N = 21 (CNT), 22 (FS-R), 19 (FS-V). D Corticosterone (CORT) serum levels. One-way ANOVA; N = 5 (CNT), 8 (FS-R), 7 (FS-V). E Mineralocorticoid receptor (MR) protein expression levels in PFC nuclear fraction. One-way ANOVA; N = 10 (CNT), 11 (FS-R), 8 (FS-V). F Glucocorticoid receptor (GR) protein expression levels in PFC nuclear fraction. One-way ANOVA; N = 9 (CNT), 11 (FS-R), 8 (FS-V). G phospho-Ser203-GR/GR protein expression levels in PFC nuclear fraction. One-way ANOVA; N = 10 (CNT), 11 (FS-R), 8 (FS-V).

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