Fig. 4: Translating ribosome affinity purification on MOR-expressing neurons targeted at the paraventricular nucleus of the thalamus. | Translational Psychiatry

Fig. 4: Translating ribosome affinity purification on MOR-expressing neurons targeted at the paraventricular nucleus of the thalamus.

From: Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations

Fig. 4: Translating ribosome affinity purification on MOR-expressing neurons targeted at the paraventricular nucleus of the thalamus.The alternative text for this image may have been generated using AI.

A Heatmap of significantly differentially expressed genes in PVT MOR-expressing neurons of controls compared to mice maintained on chronic morphine. B Volcano plot showing −log10P value vs log2 fold change (morphine vs ctl group) for all genes analyzed. Genes corresponding to significant adjusted P values are those above the dashed horizontal line. Dashed vertical lines correspond to a threshold of 1 for the absolute log2 fold change. C Significant KEGG pathways from ORA analyses of DE genes. D Enrichment plot of the Circadian Entrainment pathway. E Heatmap of the genes in the leading edge of the Circadian Entrainment pathway.

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