Fig. 2: BrainGENIE recapitulates disorder-related changes in gene expression found in postmortem brain.
From: BrainGENIE: The Brain Gene Expression and Network Imputation Engine
Concordance of case-control differential gene expression (DGE) signals obtained by BrainGENIE and S-PrediXcan compared to A DGE signals derived from postmortem cortical microarray meta-analyses for ASD, BD, and SCZ, B DGE signals derived from RNA-sequencing analysis for ASD, BD, and SCZ by the PsychENCODE Consortium, and C DGE signals obtained from postmortem prefrontal cortex RNA-sequencing analysis for SCZ by the CommonMind Consortium. ASD autism spectrum disorder, BD bipolar disorder, and SCZ schizophrenia. Symbols for significance thresholds: p < 0.05 (*), FDRp ≤ 1 × 10−5 (***), FDRp ≤ 1 × 10−10 (#), FDRp ≤ 1 × 10−20 (##).
