Fig. 3: Estimated cell-type proportions for human and macaque DLPFC samples. | Translational Psychiatry

Fig. 3: Estimated cell-type proportions for human and macaque DLPFC samples.

From: Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia

Fig. 3: Estimated cell-type proportions for human and macaque DLPFC samples.

a Cell-type proportions of excitatory neurons (ExN), inhibitory neurons (InN), and astrocytes (Astro) in bulk DLPFC tissue of SCZ cases with different toxicological profiles (groups as in Fig. 1a) estimated via corresponding single-nucleus RNA-seq profiles. Kruskal–Wallis test (KWt) on all groups: pExN = 0.908; pInN = 0.0318; pAstro = 0.0689; KWt within SCZ subgroups only: pExN = 0.798; pInN = 0.875; pAstro = 0.565. Mann–Whitney U-test (MWU) between SCZ and controls was significant for InN (p = 0.00159) and Astro (p = 0.0176). Only InN remained significant after FDR correction. b Estimated proportions of ExN, InN, and Astro in bulk DLPFC of monkeys treated with clozapine (CLZ), haloperidol (low dose: HAL.lo; high dose: HAL.hi), or placebo. KWt: pExN = 0.0433; pInN = 0.547; pAstro = 0.336. MWU between APDs and placebo was significant only for HAL.hi in ExN (p = 0.0379). For detailed test statistics, see Supplementary Table S2. For the other cell types, see Supplementary Fig. S5.

Back to article page