Fig. 1: Statins and antidepressants induced similar transcriptomic responses in HA1E cells.

A Statin and antidepressant reference signatures ranked by average connectivity (Tau) scores to the six statin query signatures. Lengths of the coloured bars represent the number of compounds with the corresponding average Tau scores (red: Tau > 90; grey: −90 ≤ Tau ≤ 90; blue: Tau < −90). Antidepressants with an average Tau score higher than 90 are shown. B Biological processes identified as significantly enriched among genes perturbed by both statins and antidepressants, in the same (left panel) and opposite (right panel) directions. Y-axis shows the ancestor GO biological process terms, as well as the child terms of primary metabolic process (GO:0044238) (a child term of “metabolic process”) and immune system process (GO:0002376). Arrows indicate ancestor-to-child relationships between GO terms. The bubble plots show the antidepressants for which the biological processes were identified as significantly enriched (gSCS-corrected p-value < 0.05) in at least one statin-antidepressant pair.