Fig. 1: Schematic illustration of study procedure and methods. | Translational Psychiatry

Fig. 1: Schematic illustration of study procedure and methods.

From: Disrupted longitudinal restoration of brain connectivity during weight normalization in severe anorexia nervosa

Fig. 1

Brain images of patients with anorexia nervosa (AN) were acquired at three time points (TP1, TP2, TP3) over the course of weight normalization. Healthy controls (HC) were scanned twice (TP1, TP3). Functional MRI data were processed and parcellated with an adapted version of the automated anatomical labelling atlas with 94 nodes [44]. Intrinsic connectivity was calculated as Pearson correlation between the mean time series of any pair of two nodes [94×94], standardized with Fisher’s r-to-z transformation. Global network strength was computed as the whole brain average of all positive connections per person. Subnetworks of altered connections were analyzed using the network-based statistic tool [47]. Global network topology was captured using characteristic path length (shortest average path length) as a measure of integration, and clustering coefficient (ratio between closed triplets relative to all triplets) and global modularity (ratio between within cluster connections to all connections) as a measure of segregation [29].

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