Fig. 3: Subnetworks of underconnectivity in patients with severe AN compared to HC.

Network nodes were defined using an adapted version of the automated anatomical labelling atlas with 94 regions [44]. A At TP1, patients with AN showed decreased functional connectivity in a large subnetwork, encompassing subcortical, limbic, insular, frontal, central, occipital, and temporal regions (pFWE < 0.004, nodes 61, connections 125). B At TP3, a subnetwork of persistent underconnectivity in patients with AN emerged (pFWE = 0.0308; nodes 33, connections 48).