Fig. 4: Global network topology compared between patients with AN (red) and healthy controls (blue).

Proportional thresholds ranged from 0.05 to 0.45 at 0.01 intervals. A–C At TP1, cluster-based permutation testing revealed statistically significant group differences (gray-shaded areas) in characteristic path length (pFWE = 0.0002, k = 23), clustering coefficient (pFWE = 0.0001, k = 37) and modularity (pFWE = 0.0001, k = 10). D+E Longitudinally, there was no evidence of group changes over time (TP3-TP1) in all three topological measures. k = empirical cluster size.