Table 2 Annotation of independent genome-wide significant associations for MCI-MRS and BAIBA in HCHS/SOL sample set B.
Effect allele frequency in Hispanic/Latino ancestry | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Outcome | Variant | Chromosome | Position (hg38) | Eff. allele | Non-eff. allele | R2 | European | African | Amerindian | Beta | p value | Gene | Annotation |
MCI-MRS (n = 3890) | rs37371 | 5 | 35040125 | G | A | 0.995 | 0.920 | 0.983 | 0.412 | 0.232 | 1.76E-15 | AGXT2 | intron |
rs344515 | 5 | 35025665 | A | G | 0.994 | 0.621 | 0.633 | 0.876 | −0.192 | 1.80E-14 | AGXT2 | intron | |
BAIBA (n = 3863) | rs16899972 | 5 | 34998673 | A | C | 1.000 | 0.509 | 0.287 | 0.475 | 0.287 | 4.75E-38 | AGXT2 | missense |
rs183958240 | 5 | 35002671 | G | A | 0.947 | 0.010 | 0.010 | 0.031 | −0.811 | 1.81E-12 | AGXT2 | missense | |
rs13174311 | 5 | 35032240 | T | C | 0.998 | 0.355 | 0.100 | 0.023 | −0.321 | 4.13E-32 | AGXT2 | intron | |
rs180749 | 5 | 35033500 | A | G | 1.000 | 0.990 | 0.816 | 0.908 | 1.423 | 1.63E-192 | AGXT2 | missense | |
rs37369 | 5 | 35037010 | T | C | 0.998 | 0.070 | 0.639 | 0.576 | 0.385 | 1.93E-51 | AGXT2 | splice donor | |
rs140156063 | 5 | 35037031 | A | G | 0.998 | 0.010 | 0.012 | 0.019 | 1.148 | 6.00E-14 | AGXT2 | missense | |
rs37370 | 5 | 35039381 | T | C | 1.000 | 0.921 | 0.984 | 0.414 | −0.892 | 3.59E-210 | AGXT2 | intron | |
rs11613331 | 12 | 242301 | A | G | 0.997 | 0.515 | 0.236 | 0.036 | 0.168 | 5.59E-12 | SLC6A13 | intron | |
