Table 3 Replication meta-analysis results for the genetic variants detected as associated with MCI-MRS and BAIBA in HCHS/SOL set B.

From: Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment

 

HCHS/SOL

ARIC

        
 

Set C

African American

European American

      
 

(n = 3149)

(n = 1032)

(n = 3775)

Meta-analysis

SNP

Beta

p value

Beta

P value

Beta

P value

Beta

SE

P value

Direction

Number of strata

N total

rs37371

0.148

1.66E-01

−0.607

7.42E-02

0.060

5.15E-01

0.069

0.068

3.12E-01

+-+

3

7956

rs344515

0.057

5.33E-01

0.041

7.19E-01

0.023

6.69E-01

0.033

0.043

4.42E-01

+++

3

7956

rs16899972

0.184

2.90E-02

0.269

2.01E-02

0.047

3.74E-01

0.110

0.042

8.71E-03

+++

3

7956

rs183958240

0.202

6.50E-01

−12.168

9.74E-01

−11.431

9.60E-01

0.202

0.445

6.50E-01

+--

3

7956

rs13174311

−0.231

2.51E-02

−0.088

6.13E-01

−0.028

6.09E-01

−0.074

0.047

1.14E-01

---

3

7956

rs180749

−0.293

1.27E-01

0.062

6.67E-01

0.149

8.53E-01

−0.062

0.114

5.87E-01

-++

3

7956

rs37369

0.144

1.38E-01

0.254

2.32E-02

0.061

5.23E-01

0.143

0.058

1.40E-02

+++

3

7956

rs140156063

1.722

4.32E-03

−0.027

9.41E-01

  

0.441

0.312

1.58E-01

+-?

2

4181

rs37370

0.150

1.61E-01

−0.607

7.42E-02

0.060

5.15E-01

0.070

0.068

3.08E-01

+-+

3

7956

rs11613331

−0.047

6.06E-01

0.110

3.63E-01

0.097

6.82E-02

0.067

0.043

1.21E-01

-++

3

7956

  1. Inverse-variance fixed-effects meta-analysis was used to meta-analyze results from the three replication datasets: HCHS/SOL set C, and ARIC African and European Americans.
  2. Effect sizes and SEs were estimated based on the mixed-models analysis approach.
  3. P values from tests of variant associations in each stratum were based on the score test.
  4. Heterogeneity of effects between datasets was low (p value >0.05 based on the Cochran’s heterogeneity test) for all variants.
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