Table 3 Biological pathway analysis of differentially expressed genes.

From: Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes

NAME

SIZE

ES

NES

NOM p-val

FDR

q-val

FWER p-val

(A) Enriched positively regulated pathways in SCZ (FDR < 0.05)

Killing by host of symbiont cells

27

0.93

1.80

<0.001

<0.001

<0.001

Defense response to fungus

49

0.90

1.77

<0.001

5.0E−4

0.001

Antibacterial humoral response

53

0.89

1.75

<0.001

0.001

0.001

Organ or tissue specific immune response

38

0.89

1.74

<0.001

0.001

0.001

Innate immune response in mucosa

24

0.90

1.73

<0.001

0.001

0.001

Response to fungus

60

0.87

1.72

<0.001

0.001

0.001

Defense response to gram negative bacterium

80

0.86

1.71

<0.001

0.001

0.001

Antimicrobial humoral response

114

0.83

1.68

<0.001

0.001

0.134

Antimicrobial humoral immune response mediated by antimicrobial peptide

74

0.84

1.68

<0.001

0.001

0.159

Modulation of process of another organism

22

0.88

1.68

<0.001

0.001

0.166

Negative regulation of interleukin 8 production

30

0.86

1.67

<0.001

0.001

0.227

(B) Enriched positively regulated pathways in BD (FDR < 0.05)

Modulation of process of another organism

22

0.88

1.67

<0.001

0.001

0.105

Antibacterial humoral response

53

0.85

1.66

<0.001

0.001

0.151

Response to fungus

60

0.83

1.64

<0.001

0.001

0.208

Nucleoside catabolic process

26

0.85

1.64

<0.001

0.001

0.261

  1. Significantly enriched gene ontology biological pathways (GOBP) returned from GSEA on preranked gene list where rank = FC*(−log10(adj.p-value)).
  2. SIZE Number of genes from the expression data set that was found in the gene set. ES Enrichment score (the degree to which a gene set is overrepresented), NES Normalized enrichment score, NOM p-val Nominal P value, FDR False discovery rate, FWER Familywise-error rate.
Back to article page