Fig. 3: Psilocybin, buspirone and the head twitch response. | Translational Psychiatry

Fig. 3: Psilocybin, buspirone and the head twitch response.

From: Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

Fig. 3

a Effect of psilocybin 4.4 mg/kg, buspirone 5 mg/kg and psilocybin 4.4 mg/kg + buspirone 5 mg/kg on HTR over a 20-min measurement period. Three-way ANOVA: Time F9,288 = 5.001, p = 0.0032; Time x psilocybin F9,288 = 3.224, p = 0.001; Time × psilocybin × buspirone F9,288 = 2.687, p = 0.0072 (within subject effects). psilocybin F1,32 = 19.22, p = 0.0001; buspirone F1,32 = 7.483, p = 0.0101; psilocybin × buspirone F1,32 = 5.237, p = 0.0289 (between-subject effects). b Total HTR over 20 min. F3,32 = 12.87, p < 0.0001; ***p < 0.001 vs. vehicle, ##p = 0.0009 buspirone + psilocybin vs. psilocybin, n = 6–12 (Tukey’s multiple comparisons test).

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