Fig. 1: Results of Partial Lease Squares correlation for basolateral amygdala (BLA) functional connectivity at rest.

1-1. Comparing maturation of BLA functional connectivity, in patients with 22q11.2 deletion syndrome (22q11.2DS) and healthy controls subjects. a Design salience reveals a substantial negative loading for diagnosis. b Distribution of the brain sores across age span for each diagnostic group visualizes the loadings captured in the design salience. Brain scores are lower in patients with 22q11.2DS (negative diagnosis loading). Fitted line and 95% confidence interval are plotted to visualize the age and diagnosis interaction effect captured in the designed salience. c The patterns of brain salience could be interpreted as areas with lower BLA functional connectivity (blue), and higher functional connectivity (red) in patients with 22q11.2DS. 1-2 Comparing maturation of BLA functional connectivity in patients with and without mild to moderate impaired tolerance to stress [ITS(+) and ITS(–), respectively]. a Design salience reveals the negative effect of group as well as a negative effect of age–group interaction. b The distribution of brain scores across age in each group visualizes the captured loadings in the design salience. Accordingly, brain scores are low in ITS(+) patients and deviate further from brain scores of ITS(–) patients during development. Fitted line and 95% confidence interval are plotted to visualize the age and diagnosis interaction effect captured by partial least squares correlation in the design salience. c The pattern of brain salience shows areas with lower and more severe decrease of BLA functional connectivity in ITS(+) patients (blue).