Fig. 5: Subchronic systemic administration of 7,8-DHF reversed ELS-induced spatial memory deficits and adult neurogenesis reduction. | Translational Psychiatry

Fig. 5: Subchronic systemic administration of 7,8-DHF reversed ELS-induced spatial memory deficits and adult neurogenesis reduction.

From: The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice

Fig. 5

A The experimental timeline of the 7,8-DHF injection and behavioral procedure after stress exposure. B Schematic showing the subchronic intraperitoneal injection of 7,8-DHF into adult C57BL/6N mice. C In the SOR test, except that the ELS + Veh group failed to recognize the object placed in novel location, the other three groups performed well. D In the Y-maze test, 7,8-DHF treatment increased the spontaneous alternation ratio. E Stress-induced reduction of the number of DCX-positive cells (arrowheads) in the DG was reversed by subchronic 7,8-DHF treatment. Scale bar = 100 µm or 10 µm. AAR alternate arm return, Acc. acclimation, CT control, DHF 7,8-dihydroxyflavone, ELS early-life stress, PND postnatal day, SA spontaneous alternation, SAR same arm return, SOR spatial object recognition, Veh vehicle. *p < 0.05, **p < 0.01, Tukey’s post hoc test; @p < 0.05, @@p < 0.01, the main effect of drug.

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