Fig. 3: PPARα deficiency reduces intrinsic excitability of dentate gyrus (DG) granule neurons. | Translational Psychiatry

Fig. 3: PPARα deficiency reduces intrinsic excitability of dentate gyrus (DG) granule neurons.

From: Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons

Fig. 3

a Action potential (AP) trains evoked by step-current injections in DG granule neurons of PPARα−/− (red) and WT littermates (black). b. Number of APs (genotype: F (1,94) = 5.078, p = 0.0266; current: F (12,1128) = 169.9, p < 0.0001; genotype × current: F (12,1128) = 3.449, p < 0.0001). c Rheobase current (t(94) = 2.223, p = 0.0286). d Input resistance (IR). Left, input resistance (t(94) = 2.306, p = 0.0233). Right, IR vs rheobase of DG granule neorns. e Resting membrane potential. Left, resting membrane potential (t(94) = 4.627, p < 0.0001). Right, RMP vs rheobase of DG granule neurons. f Representative action potential waveform during ramp depolarization. g AP amplitude (t(94) = 1.653, p = 0.1016). h AP half-width (t(94) = 2.642, p = 0.0096). i Post-burst afterhyperpolarization (AHP)(t(94) = 3.822, p = 0.0002). PPARα−/−, n = 49 neurons from 5 mice; WT, n = 47 neurons from 5 mice. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 compared with WT littermate control. Data are presented as mean ± s.e.m.

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