Table 2 Genomic risk loci for AAO identified in the genome-wide meta-analysis.
From: Common genetic variants contribute to heritability of age at onset of schizophrenia
Genomic Locus | Positiona | Lead SNP | Lead SNP position | P-value | nSNPsb | Genes |
|---|---|---|---|---|---|---|
1 | 1:181854925 | rs185188889 | 1:181854925 | 6.735e−06 | 1 | – |
2 | 2:81911239:82893571 | rs13383639 | 82802994 | 7.8040E−06 | 19 | REG3G, REG1B, REG3A, CTNNA2, LRRTM1, SUCLG1 |
3 | 3:173494302:173563936 | rs7652242 | 173553275 | 4.57E−06 | 59 | NLGN1, NAALADL2 |
4 | 4:30196116:30196116 | rs111289733 | 30196116 | 1.66E−07 | 1 | RP11-180C1.1 |
5 | 4:38573143:38604331 | rs4833071 | 38582859 | 4.79E−06 | 12 | RELL1, TBC1D1, PTTG2, AC021860.1, KLF3, TLR10, RFC1, UGDH |
6 | 4:40443966:40443966 | rs10755175 | 40443966 | 4.49E−06 | 1 | RHOH, RBM47, NSUN7 |
7 | 4:167064039:167096817 | rs10018884 | 167092502 | 2.36E−06 | 65 | MARCH1, MSMO1, SPOCK3, ANXA10, DDX60, PALLD |
8 | 5:108260989:108520863 | rs78438786 | 108260989 | 6.72E−07 | 6 | FER, PJA2, MAN2A1, TMEM232, SLC25A46 |
9 | 5:120718453:120901978 | rs2195409 | 120892594 | 6.73E−06 | 34 | DMXL1, HSD17B4, FAM170A, FTMT, SRFBP1, LOX, SNCAIP |
10 | 5:133457000:133774168 | rs4431386 | 133557876 | 2.54E−06 | 65 | SLC22A5, C5orf56, IL4, KIF3A, CCNI2, GDF9, UQCRQ, LEAP2, AFF4, ZCCHC10, HSPA4, C5orf15, VDAC1, TCF7, SKP1, CTD-2410N18.5, PPP2CA, CDKL3, UBE2B, CDKN2AIPNL, JADE2, SAR1B, SEC24A, DDX46, C5orf24, TXNDC15, PCBD2, PITX1 |
11 | 7:48751259:48840965 | rs139864446 | 48831950 | 9.07E−06 | 7 | AC004899.1, VWC2, C7orf72, IKZF1, DDC |
12 | 7:106206611:106399401 | rs111513327 | 106207969 | 1.75E−06 | 7 | EFCAB10, ATXN7L1, SYPL1, NAMPT, CCDC71L, PIK3CG, PRKAR2B, HBP1, COG5, DUS4L, BCAP29, SLC26A4, CBLL1, SLC26A3 |
13 | 8:20289797:20370404 | rs12550821 | 20315601 | 4.85E−06 | 32 | CSGALNACT1, LPL, SLC18A1, ATP6V1B2, LZTS1, GFRA2, DOK2, XPO7, LGI3, SFTPC, BMP1 |
14 | 8:121006828:121262332 | rs10808509 | 121227216 | 5.61E−06 | 77 | TAF2, DSCC1, DEPTOR, COL14A1, MRPL13, MTBP, SNTB1 |
15 | 11:2192798:2192798 | rs10840489 | 2192798 | 2.04E−06 | 1 | KRTAP5-4, KRTAP5-5, KRTAP5-6, IFITM10, RP11-295K3.1, CTSD, SYT8, TNNI2, LSP1, C11orf89, TNNT3, TH, C11orf21 |
16 | 11:44644743:44870058 | rs11038082 | 44644743 | 2.51E−06 | 28 | C11orf96, EXT2, ALX4, CD82, TSPAN18, TP53I11, PRDM11, SYT13, SLC35C1, CRY2 |
17 | 12:32500207:32537185 | rs144642024 | 32500207 | 1.58E−06 | 2 | OVCH1, FAM60A, AC024940.1, DENND5B, METTL20, AMN1, KIAA1551, FGD4, DNM1L, YARS2, ALG10 |
18 | 13:61356260:61390956 | rs9570366 | 61377708 | 1.69E−06 | 19 | PCDH20 |
19 | 14:20479798:20546983 | rs72667672 | 20492904 | 6.82E−06 | 82 | OR4N2, OR4K2, OR4K5, OR4K1, OR4K14, OR4K13, OR4L1, OR4K17, OR4N5, TTC5, RNASE9, RNASE4, ANG, AL163636.6 |
20 | 16:71388416:71388416 | rs142248381 | 71388416 | 2.45E−07 | 1 | COG4, SF3B3, MTSS1L, VAC14, HYDIN, CMTR2, ZNF23, ZNF19, TAT, HP, HPR |
21 | 16:84318421:84322649 | rs11645140 | 84322546 | 5.17E−07 | 4 | NECAB2, MBTPS1, HSDL1, DNAAF1, KCNG4, WFDC1, ATP2C2 |
22 | 17:51482920:52487345 | rs146709267 | 52065109 | 1.48E−06 | 11 | MBTD1, UTP18, CA10, AC102948.2, C17orf112, KIF2B, TOM1L1, COX11, STXBP4, HLF, MMD, ANKFN1, NOG |
