Table 4 Top3 mtDNAs identified in MiWAS for depression (p < 0.05).
Gender | Phenotype | Variant | mtDNA | BETA | SE | P value |
|---|---|---|---|---|---|---|
Total | Self-reported depression | m.709G>A | MT-RNR1 | 0.0151 | 0.004715 | 1.40 × 10−3 |
Total | Self-reported depression | m.10463T>C | MT-TR | 0.015 | 0.005443 | 5.79 × 10−3 |
Total | Self-reported depression | m.3915G>A | MT-ND1 | 0.0264 | 0.01005 | 8.74 × 10−3 |
male | Self-reported depression | m.3915G>A | MT-ND1 | 0.0403 | 0.01489 | 6.86 × 10−3 |
male | Self-reported depression | m.709G>A | MT-RNR1 | 0.0182 | 0.00695 | 8.77 × 10−3 |
male | Self-reported depression | m.13965T>C | MT-ND5 | 0.0428 | 0.02182 | 4.97 × 10−2 |
female | Self-reported depression | m.3394T>C | MT-ND1 | −0.043 | 0.01967 | 2.73 × 10−2 |
female | Self-reported depression | m.10463T>C | MT-TR | 0.0156 | 0.007394 | 3.44 × 10−2 |
female | Self-reported depression | m.3010G>A | MT-RNR2 | −0.011 | 0.00518 | 3.85 × 10−2 |
Total | PHQ-9 | m.9899T>C | MT-CO3 | −0.336 | 0.1166 | 3.94 × 10−3 |
Total | PHQ-9 | m.11914G>A | MT-ND4 | 0.2986 | 0.1103 | 6.81 × 10−3 |
Total | PHQ-9 | m.15257G>A | MT-CYB | 0.2538 | 0.0978 | 9.47 × 10−3 |
male | PHQ-9 | m.11914G>A | MT-ND4 | 0.5641 | 0.1508 | 1.84 × 10−4 |
male | PHQ-9 | m.6776T>C | MT-CO1 | −0.221 | 0.09361 | 1.85 × 10−2 |
male | PHQ-9 | m.73A>G | MT-DLOOP | −0.097 | 0.04183 | 2.06 × 10−2 |
female | PHQ-9 | m.4580G>A | MT-ND2 | 0.3174 | 0.1124 | 4.74 × 10−3 |
female | PHQ-9 | m.16193C>T | MT-DLOOP | 0.4135 | 0.1805 | 2.20 × 10−2 |
female | PHQ-9 | m.9899T>C | MT-CO3 | −0.377 | 0.1716 | 2.81 × 10−2 |
