Fig. 1: Plasma concentrations of total LPA and LPA species in the sample based on the diagnosis of CUD and sex.

A Total LPA concentrations; (B) 16:0-LPA concentrations; (C) 18:0-LPA concentrations; (D) 18:1-LPA concentrations; (E) 18:2-LPA concentrations; and (F) 20:4-LPA concentrations. Dots are individual values. Bars represent the estimated marginal means and 95% CI of log10-transformed concentrations of total LPA and LPA species. Data were analyzed using two-way ANCOVA controlling for age and BMI. F-statistics and p-values of ANCOVA are shown. G Correlations between plasma concentrations of 20:4-LPA and age of onset cocaine use (years); and (H) duration of cocaine abstinence (days). Correlations analyses was performed using the Pearson’s correlation coefficient (r). Dots are individual values. Blue solid line and black dashed lines represent linear fit and 95% CI, respectively.