Fig. 3: Irradiation and lithium treatment alter the DNA methylation status of gene promoters important for neurogenesis and control of transcription in hNSPCs. | Translational Psychiatry

Fig. 3: Irradiation and lithium treatment alter the DNA methylation status of gene promoters important for neurogenesis and control of transcription in hNSPCs.

From: Irradiation and lithium treatment alter the global DNA methylation pattern and gene expression underlying a shift from gliogenesis towards neurogenesis in human neural progenitors

Fig. 3

a–b Volcano plot depicting the top enriched gene ontology terms in the category (a) “Biological process” and (b) “Molecular function”, for the genes with significantly hypomethylated promoter regions in the IR + LiCl group vs the IR only group (n = 510 genes, with deltaBeta <−0.05, p < 0.05 in 5’ UTR region), made with WebGestalt (parameters of analysis: enrichment method: ORA, enrichment category: geneontology, Fisher’s exact test, FDR < 0.05). c Pie charts depicting GO term analysis on the DNA binding transcription activity category. Presented in order, 82 demethylated genes (IR vs Control), 110 (LiCl + IR vs Control), 123 (LiCl + IR vs IR).

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