Fig. 4: Overlap between Mbd2−/− mice hippocampal transcriptome, human brain transcriptomes in psychiatric disorders and ASD-risk genes.
From: Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition
A Heatmap of log10(p-values) of differentially expressed gene overlap between Mbd2−/− mice and ASD, schizophrenia and bipolar disorder human brain. Numbers within the heatmap indicate -log10(p-values). B Pearson’s correlations of fold-changes in gene-expression levels between Mbd2−/− mice and ASD (n = 286 genes), schizophrenia (n = 686 genes) and bipolar disorder human brain (n = 137 genes). C An overlap analysis revealed a significant intersection between human ASD high risk genes and downregulated (Top) but not upregulated (Bottom) genes in Mbd2−/− hippocampi. D An overlap analysis revealed a significant intersection between human ASD risk genes based on the SFARI Gene Project and downregulated (Top) but not upregulated (Bottom) genes in Mbd2−/−. (Hypergeometric tests). E Western blot analysis showing reduced protein levels of Drd2, Pogz and Zbtb16 in Mbd2−/− mice hippocampi. Proteins molecular weights as determined using molecular weight markers are indicated. Note: circle sizes are not to scale.
