Fig. 2: Brain developmental changes in ATP, phosphocreatine (PCr), Intracellular phosphate (Piint), pH, [Mg2+], phosphoester ratio PME/PDE, and UDP(G) in WT and gclm-KO mice. | Translational Psychiatry

Fig. 2: Brain developmental changes in ATP, phosphocreatine (PCr), Intracellular phosphate (Piint), pH, [Mg2+], phosphoester ratio PME/PDE, and UDP(G) in WT and gclm-KO mice.

From: Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia

Fig. 2

Changes of [ATP], [PCr], [Pi int], pH, [Mg2+], PME/PDE and UDP(G) from postnatal day P20 to P250 in the brain of WT and gclm-KO mice. a Gclm-KO mice demonstrated significant increases in ATP at P20 and P90 relative to WT mice. All values are shown as mean ± SEM and significant differences are derived from the post hoc Bonferroni correction test for multiple comparisons. *P < 0.05. b Levels of UDP(G) were obtained from the pooled summed spectra, respectively at P20, P40, P90, and P250. A stable level along development was observed in WT mice, while a decrease after P90 occurred in gclm-KO mice.

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