Table 3 Estimated means with 95% confidence interval (CI) for clinical outcomes differed by potential disease biometrics.
From: Immunotherapy responsiveness and risk of relapse in Down syndrome regression disorder
On therapy | After therapy | |||||||
|---|---|---|---|---|---|---|---|---|
Mean change from baseline | SE | 95% CI | P value | Mean change from baseline | SE | 95% CI | P value | |
25-Foot walk | ||||||||
With catatonia | −2.39 | 0.40 | [−3.17, −1.62] | 0.0000 | −0.75 | 0.33 | [−1.40, −0.09] | 0.0254 |
Without catatonia | 0.13 | 0.65 | [−1.15, 1.41] | 0.8457 | 0.78 | 0.55 | [−0.30, 1.86] | 0.1580 |
With any neurodiagnostic abnormalities | −3.14 | 0.60 | [−4.32, −1.96] | 0.0000 | 0.31 | 0.551 | [−0.68, 1.30] | 0.5397 |
Without any neurodiagnostic abnormalities | −1.00 | 0.50 | [−1.97, −0.02] | 0.0447 | −0.86 | 0.42 | [−1.68, −0.05] | 0.0379 |
Prior immunotherapy | −4.05 | 1.61 | [−7.21, −0.89] | 0.0120 | −4.07 | 1.26 | [−6.55, −1.60] | 0.0013 |
No prior immunotherapy | −1.60 | 0.37 | [−2.31, −0.88] | 0.0000 | −0.14 | 0.29 | [−0.71, 0.42] | 0.6130 |
Bush–Francis Score | ||||||||
With catatonia | −8.45 | 0.84 | [−10.10, −6.80] | 0.0000 | −5.45 | 0.85 | [−7.11, −3.79] | 0.0000 |
Without catatonia | −1.86 | 1.39 | [−4.59, 0.87] | 0.1811 | −1.64 | 1.40 | [−4.38, 1.11] | 0.2432 |
With any neurodiagnostic abnormalities | −9.86 | 1.30 | [−12.41, −7.32] | 0.0000 | −3.45 | 1.29 | [−5.98, −0.92] | 0.0075 |
Without any neurodiagnostic abnormalities | −5.28 | 1.07 | [−7.37, −3.19] | 0.0000 | −5.56 | 1.06 | [−7.63, −3.48] | 0.0000 |
EEG abnormal | −10.42 | 1.62 | [−13.60, −7.24] | 0.0000 | −6.00 | 1.60 | [−9.14, −2.86] | 0.0002 |
EEG normal | −5.94 | 0.97 | [−7.85, −4.04] | 0.0000 | −4.25 | 0.96 | [−6.12, −2.37] | 0.0000 |
MRI abnormal | −8.44 | 1.83 | [−12.02, −4.85] | 0.0000 | −1.56 | 1.70 | [−4.90, 1.78] | 0.3590 |
MRI normal | −6.75 | 0.98 | [−8.67, −4.83] | 0.0000 | −5.61 | 0.91 | [−7.39, −3.82] | 0.0000 |
LP abnormal | −9.42 | 1.41 | [−12.17, −6.66] | 0.0000 | −1.67 | 1.15 | [−3.92, 0.59] | 0.1470 |
LP normal | −6.25 | 0.63 | [−7.48, −5.02] | 0.0000 | −3.55 | 0.51 | [−4.56, −2.54] | 0.0000 |
Prior immunotherapy | −9.00 | 3.58 | [−16.01, −1.99] | 0.0119 | −11.25 | 3.31 | [−17.73, −4.77] | 0.0007 |
No prior immunotherapy | −6.56 | 0.81 | [−8.15, −4.98] | 0.0000 | −4.08 | 0.75 | [−5.54, −2.61] | 0.0000 |
CGI-Severity Score | ||||||||
With catatonia | −1.58 | 0.27 | [−2.10, −1.06] | 0.0000 | −0.63 | 0.14 | [−0.92, −0.35] | 0.0000 |
Without catatonia | −0.41 | 0.44 | [−1.27, 0.45] | 0.3519 | −0.91 | 0.24 | [−1.38, −0.44] | 0.0001 |
With any neurodiagnostic abnormalities | −2.21 | 0.38 | [−2.96, −1.46] | 0.0000 | −0.45 | 0.21 | [−0.86, −0.04] | 0.0324 |
Without any neurodiagnostic abnormalities | −0.81 | 0.31 | [−1.43, −0.20] | 0.0096 | −1.00 | 0.17 | [−1.34, −0.66] | 0.0000 |
MRI abnormal | −2.31 | 0.53 | [−3.35, −1.28] | 0.0000 | −0.19 | 0.28 | [−0.73, 0.36] | 0.5018 |
MRI normal | −1.11 | 0.28 | [−1.66, −0.55] | 0.0001 | −0.95 | 0.15 | [−1.24, −0.65] | 0.0000 |
LP abnormal | −2.58 | 0.61 | [−3.77, −1.39] | 0.0000 | −0.33 | 0.33 | [−0.98, 0.31] | 0.3128 |
LP normal | −1.13 | 0.27 | [−1.67, −0.60] | 0.0000 | −0.87 | 0.15 | [−1.16, −0.58] | 0.0000 |
Total NPI Score | ||||||||
With catatonia | −7.40 | 0.59 | [−8.55, −6.25] | 0.0000 | −3.22 | 0.50 | [−4.20, −2.23] | 0.0000 |
Without catatonia | −4.05 | 0.97 | [−5.95, −2.14] | 0.0000 | −2.68 | 0.83 | [−4.31, −1.05] | 0.0012 |
With any neurodiagnostic abnormalities | −9.55 | 0.83 | [−11.17, −7.93] | 0.0000 | −2.03 | 0.73 | [−3.46, −0.61] | 0.0052 |
Without any neurodiagnostic abnormalities | −4.91 | 0.68 | [−6.24, −3.58] | 0.0000 | −4.05 | 0.60 | [−5.22, −2.88] | 0.0000 |
EEG abnormal | −10.00 | 1.06 | [−12.08, −7.92] | 0.0000 | −2.11 | 0.91 | [−3.90, −0.31] | 0.0213 |
EEG normal | −5.62 | 0.63 | [−6.87, −4.38] | 0.0000 | −3.64 | 0.55 | [−4.71, −2.57] | 0.0000 |
MRI abnormal | −10.13 | 1.17 | [−12.42, −7.83] | 0.0000 | −1.81 | 0.99 | [−3.76, 0.13] | 0.0678 |
MRI normal | −5.82 | 0.62 | [−7.05, −4.60] | 0.0000 | −3.64 | 0.53 | [−4.68, −2.60] | 0.0000 |
LP abnormal | −9.42 | 1.41 | [−12.17, −6.66] | 0.0000 | −1.67 | 1.15 | [−3.92, 0.59] | 0.1470 |
LP normal | −6.25 | 0.63 | [−7.48, −5.02] | 0.0000 | −3.55 | 0.51 | [−4.56, −2.54] | 0.0000 |
