Table 1 Tract metrics and treatment response.

From: Poor response to methylphenidate is associated with a smaller dorsal attentive network in adult Attention-Deficit/Hyperactivity Disorder (ADHD)

TRACT METRIC

LOGISTIC REGRESSION

ROC

FAMILY-WISE CORRECTION

 

B

Wald’s X2

p-value

AUC

Sens. (%)

Spec. (%)

Est.

Z-value

Corr. p-value

Left SLF I volume

0.255

6.955

0.008

0.709

76.9

70.6

0.255

2.637

0.038

SLF I LI

−3.627

5.254

0.022

0.689

96.2

45.5

−3.627

−2.292

0.075

Left AT HMOA

−101.364

4.387

0.036

0.663

65.4

61.8

−33.092

−0.692

0.997

  1. The first columns display the statistically significant results of the logistic regression testing the relationship between tract metrics and treatment response (i.e., the classification responders/non-responders based on k-mean clustering). The following three columns report AUC, specificity, and sensitivity at optimal cut-off of the corresponding ROC curves. Finally, the last three columns display family-wise correction for multiple comparisons. Statistically significant results are reported in bold. The left SLF I volume was the strongest associate of treatment response and survived correction for multiple comparisons (number of tracts = 10).
  2. AT anterior thalamic, AUC area under the curve, B tract metric regression coefficient, Corr corrected, Est estimate, HMOA hindrance modulated orientational anisotropy, LI lateralization index, ROC receiver operating characteristic, Sens sensitivity at optimal cut-off, SLF superior longitudinal fasciculus, Spec specificity at optimal cut-off.
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