Fig. 2: Cognitive performance of MCCB at each time point between the antipsychotics plus metformin group and the antipsychotics alone group.

Values are presented as mean and standard error estimated from linear mixed-effects models. Abbreviations: MCCB, MATRICS Consensus Cognitive Battery; W0, baseline; W12, week 12; W24, week 24. For the simple effect of metformin treatment at week 12/24 based on linear mixed-effects models, *P < 0.05, **P < 0.01, ***P < 0.001.