Fig. 4: Longitudinal changes of ROI-based voxel-wise FC in the antipsychotics plus metformin group compared with the antipsychotics alone group over 12 weeks and correlations with MCCB composite score. | Translational Psychiatry

Fig. 4: Longitudinal changes of ROI-based voxel-wise FC in the antipsychotics plus metformin group compared with the antipsychotics alone group over 12 weeks and correlations with MCCB composite score.

From: Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex

Fig. 4: Longitudinal changes of ROI-based voxel-wise FC in the antipsychotics plus metformin group compared with the antipsychotics alone group over 12 weeks and correlations with MCCB composite score.

a Significant clusters showing time × group interaction effects in FC with DLPFC subregions as seeds between two groups from baseline to week 12 (cluster-wise FWE P < 0.05). b Correlations between changes of FC and MCCB composite score. Δ12-0 indicates changes of measurements between week 12 and baseline. Abbreviations: FC functional connectivity, MCCB MATRICS Consensus Cognitive Battery, DLPFC dorsolateral prefrontal cortex, FWE family-wise error, ACC anterior cingulate cortex, MCC middle cingulate cortex, SFG superior frontal gyrus, MFG middle frontal gyrus, L/R left/right. *P < 0.05.

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