Fig. 2: Effects of betaxolol on sd-METH-induced CPP in METH-sired male F1. | Translational Psychiatry

Fig. 2: Effects of betaxolol on sd-METH-induced CPP in METH-sired male F1.

From: Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC

Fig. 2: Effects of betaxolol on sd-METH-induced CPP in METH-sired male F1.

a Timeline of Experiment 1. b CPP score. c ΔCPP score. d Traveled traces in the CPP apparatus by METH-sired male F1. e Timeline of Experiment 2. f CPP score. g ΔCPP score. h Traveled traces in the CPP apparatus by METH-sired male F1. F1-METH-Ts-Vcl, vehicle bilaterally into the mPFC of METH-sired male F1 at 15 min prior to CPP test; F1-METH-Ts-Bxol, betaxolol bilaterally into the mPFC of METH-sired male F1 at 15 min prior to CPP test; F1-METH-Tr-Vcl, vehicle bilaterally into the mPFC of METH-sired male F1 during CPP training; F1-METH-Tr-Bxol, betaxolol bilaterally into the mPFC of METH-sired male F1 during CPP training. The data are presented as the Mean ± SD. Data were analyzed by two-way ANOVA followed by Sidak’s multiple comparisons test where appropriate. N.S., P > 0.05. ##P < 0.01 vs Pre-test CPP score. **P < 0.01 vs F1-METH-Ts-Vcl or F1-METH-Tr-Vcl.

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