Fig. 1: PRS1, PlacPRS1, NonPlacPRS1 and a history of obstetric complications (OCs) or birth asphyxia (ASPH) in the TOP sample of schizophrenia (SZ) patients and healthy controls (HC).
From: The impact of placental genomic risk for schizophrenia and birth asphyxia on brain development
A Association between genomic risk score (PRS1), constructed from alleles showing significant association with SZ (GWAS p < 5E-08) and case-control status. Interaction between PRS1 and OCs (scored > 3 with the McNeil–Sjöström scale, MS) on case–control status. Interaction between PRS1 and ASPH on case–control status. B Association between placental risk score (PlacPRS1), constructed from alleles showing significant association with SZ (GWAS p < 5E-08) and genes highly and differentially expressed in placentae, and case–control status. Interaction between PlacPRS1 and OCs (scored > 3 with the McNeil–Sjöström scale, MS) on case–control status. Interaction between PlacPRS1 and ASPH on case–control status. C Association between non-placental risk score (NonPlacPRS1), constructed from alleles showing significant association with SZ (GWAS p < 5E-08) and genes not expressed in placenta, and case–control status. Interaction between NonPlacPRS1 and OCs (scored > 3 with the McNeil–Sjöström scale, MS) on case–control status. Interaction between NonPlacPRS1 and ASPH on case–control status. One-tailed p values are reported for both PRS1*birth asphyxia and PlacPRS1*birth asphyxia in the Figure, based on the directionality of the findings in previous study [20, 21]. See Table 2 and main text for detailed statistics.
