Fig. 5: p11 located in synapses and was involved in regulating synaptic function.
From: Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors
A, B Top 30 enriched (normalized enrichment score, NES > 0; false-discovery rate, FDR < 0.25) and de-enriched (NES < 0, FDR < 0.25) gene sets in the CSDS DRN samples revealed by gene set enrichment analysis (GSEA). GO-BP: gene ontology – biological process, GO-CC: gene ontology – cellular component, GO-MF: gene ontology – molecular function, KEGG: the Kyoto Encyclopedia of Genes and Genomes signaling pathway. C Representative pictures of immunoelectron microscopy. p11 in presynaptic, postsynaptic, axon, and cytoplasmic or cytoplasmic (left to right). Red arrow (labeled P11), green arrow (postsynaptic compact). D left: representative graph of immunofluorescence staining of GluN2A(red, up)/GluN2B(red, down), middle representative graph of immunofluorescence staining of p11(green) and p11(blue). co-localization of GluN2A(red, up)/GluN2B(red, down) p11 (green) and dapi(blue). scale bar 50 μM.
