Fig. 1: Single-cell gene expression profiling of PFC derived from postmortem brains. | Translational Psychiatry

Fig. 1: Single-cell gene expression profiling of PFC derived from postmortem brains.

From: Does decreased autophagy and dysregulation of LC3A in astrocytes play a role in major depressive disorder?

Fig. 1: Single-cell gene expression profiling of PFC derived from postmortem brains.

A Uniform manifold approximation and projection (UMAP) map of 78,886 cells from 34 donors. Each dot represents one cell, colored according to the indicted cell types. Astro astrocytes, L5 ET layer 5 extratelencephalic-projecting neurons, L6b layer 6b neurons, Oligo oligodendrocytes, SST somatostatin-positive GABA neurons, Endo endothelial cells, L5/6 IT layer 5/6 intratelencephalic cells, OPC oligodendrocyte precursor cells, VIP vasoactive intestinal peptide-positive GABA neurons, IT intratelencephalic cells, L5/6 NP layer 5/6 near-projecting neurons, Micro-PVM microglial cells and perivascular macrophages. B Visualization of clustering results colored according to groups. C Average expression levels of marker genes in different cell clusters. D, E Heatmap and bar plot showing the odds ratios (D) and proportions (E) of the 14 major cell types in MDD and control brains. F Box plot showing the reduced proportion of PFC astrocytes in three bulk expression profiling datasets. G Bar plot showing the inferred interactions and inferred strength of cell–cell communication in each group. H Circle plot showing cell–cell communication focusing on astrocytes. Edge width represents the communication score.

Back to article page