Fig. 5: Whole-brain regressions of anhedonia symptom scores (Snaith Hamilton Pleasure Scale, SHAPS) with sgACC rsFC changes in patients with TRD (n = 15 post-ketamine and n = 12 post-placebo).

For figure A, the image shows significant clusters from seed-based resting-state functional connectivity (rsFC) analysis, cluster-thresholded at α < 0.05, with a cluster forming threshold of p < 0.001 and an extent of 24 voxels. For figure B, the image shows a dACC cluster with a threshold of p < 0.005. Graphs show correlations between absolute SHAPS scores vs. absolute sgACC-dACC rsFC (Fisher’s z-score; either ketamine and placebo [A] or ketamine alone [B]) measured two days following infusion. A sgACC-dACC rsFC was positively associated with SHAPS scores post-ketamine (R² = 0.575, p = 0.001) but was negatively associated with SHAPS scores post-placebo (R² = 0.338, p = 0.048). B After controlling for rsFC changes post-placebo, a 39-voxel dACC cluster was significant at p < 0.005 voxels and sgACC rsFC to this cluster was correlated with post-ketamine SHAPS scores (R² = 0.484, p = 0.004).