Table 2 Differences in proteins between HIP and LIP based on assigned cluster.

From: Inflammatory biotype of ADHD is linked to chronic stress: a data-driven analysis of the inflammatory proteome

Cluster

Protein

LIP

HIP

HIP vs. LIP

(N = 73)

(N = 53)

mean

sd

mean

sd

F1

p value1

p.adj2

Cluster 1

EN-RAGE

2.14

0.60

2.31

0.69

2.78

0.098

0.245

CCL23

9.66

0.47

9.73

0.44

0.81

0.368

0.461

CD8A

9.45

0.62

9.59

0.67

1.31

0.255

0.425

NT-3

1.88

0.36

2.10

0.48

9.30

0.003

0.014

SCF

9.11

0.34

9.08

0.36

0.17

0.682

0.682

Cluster 2

DNER

8.40

0.26

8.43

0.23

0.50

0.481

0.578

uPA

9.38

0.22

9.59

0.26

25.55

<0.001

<0.001

TWEAK

8.51

0.26

8.64

0.27

7.92

0.006

0.017

CST5

5.99

0.43

6.15

0.46

4.01

0.048

0.111

OPG

9.64

0.28

9.85

0.30

16.47

<0.001

0.001

CCL28

2.19

0.32

2.38

0.39

9.33

0.003

0.011

MMP-10

8.98

0.74

8.94

0.72

0.09

0.758

0.827

TNFB

4.61

0.40

4.54

0.34

1.06

0.305

0.523

LIF-R

3.72

0.21

3.75

0.22

0.57

0.45

0.578

Flt3L

8.59

0.39

8.72

0.41

3.75

0.055

0.111

CX3CL1

3.82

0.35

3.88

0.37

0.82

0.366

0.549

FGF-19

7.75

0.83

7.74

0.95

<0.01

0.955

0.955

Cluster 3

FGF-23

1.84

0.30

1.91

0.31

2.54

0.114

0.152

IL-18R1

7.71

0.37

7.86

0.47

4.57

0.035

0.069

HGF

7.68

0.35

8.09

0.43

36.93

<0.001

<0.001

OSM

4.18

0.80

4.08

0.88

0.51

0.475

0.475

TGF-α

2.41

0.25

2.46

0.23

1.42

0.236

0.27

IL6

1.70

0.49

1.87

0.52

3.33

0.071

0.113

FGF-21

4.54

1.13

5.08

1.42

5.73

0.018

0.048

CCL19

8.59

0.62

8.87

0.70

7.73

0.006

0.025

Cluster 4

CCL25

5.62

0.46

5.92

0.48

12.92

<0.001

0.001

CDCP1

2.04

0.48

2.33

0.69

7.99

0.006

0.007

IL18

8.32

0.52

8.75

0.55

19.85

<0.001

<0.001

MCP-1

10.48

0.36

10.68

0.35

8.99

0.003

0.005

CCL11

7.22

0.41

7.35

0.50

9.55

0.095

0.095

TRAIL

7.52

0.30

7.67

0.27

8.15

0.005

0.007

IL-10RB

5.74

0.26

5.94

0.26

19.20

<0.001

<0.001

CD5

4.94

0.27

5.10

0.28

10.59

0.001

0.003

VEGFA

10.41

0.29

10.77

0.36

38.99

<0.001

<0.001

CSF-1

9.68

0.19

9.80

0.19

11.00

0.001

0.003

TNF

2.05

0.33

2.29

0.30

17.67

<0.001

<0.001

IL-15RA

0.94

0.08

0.98

0.16

3.52

0.063

0.068

SLAMF1

2.10

0.30

2.22

0.40

3.87

0.052

0.061

Cluster 5

CD6

5.88

0.42

6.06

0.38

-

-

-

TNFRSF9

6.21

0.35

6.34

0.35

-

-

-

TRANCE

4.47

0.63

4.50

0.65

-

-

-

CXCL10

8.94

0.80

9.20

0.71

-

-

-

CXCL9

6.04

0.66

6.13

0.50

-

-

-

IFN-γ

6.23

0.80

6.36

0.81

-

-

-

IL-12B

5.85

0.56

5.79

0.60

-

-

-

Cluster 6

ADA

5.04

0.32

5.68

0.62

72.53

<0001

<0.001

CD40

10.46

0.37

11.67

0.49

344.60

<0.001

<0.001

SIRT2

3.95

1.08

7.29

1.13

387.69

<0.001

<0.001

AXIN1*

3.68

1.70

7.58

1.10

514.12

<0.001

<0.001

STAMBP

4.26

0.97

7.53

1.04

622.81

<0.001

<0.001

CD244

5.66

0.25

6.43

0.43

185.77

<0.001

<0.001

PD-L1

4.96

0.24

5.61

0.38

149.54

<0.001

<0.001

EIF4EBP1

7.51

0.70

9.73

0.83

369.42

<0.001

<0.001

CASP8

1.71

0.28

2.76

0.59

223.47

<0.001

<0.001

TNFSF14

3.52

0.49

4.69

0.54

167.40

<0.001

<0.001

ST1A1*

2.53

0.61

3.73

0.56

143.19

<0.001

<0.001

CCL3

4.61

0.36

5.23

0.43

78.04

<0.001

<0.001

CCL4

5.13

0.47

5.81

0.51

59.69

<0.001

<0.001

MCP-2

7.84

0.58

8.67

0.63

59.18

<0.001

<0.001

LAPTGF β-1

5.34

0.28

6.32

0.49

206.91

<0.001

<0.001

CXCL6

7.40

0.68

9.03

0.78

190.25

<0.001

<0.001

MCP-4

12.87

0.60

14.21

0.71

128.95

<0.001

<0.001

CXCL11

6.58

0.70

7.91

0.77

110.46

<0.001

<0.001

CXCL5

9.80

1.41

12.24

0.77

146.55

<0.001

<0.001

CXCL1

8.92

0.93

10.49

0.76

116.35

<0.001

<0.001

IL-8

3.99

0.45

4.69

0.51

67.17

<0.001

<0.001

IL-7

1.71

0.51

2.76

0.58

152.07

<0.001

<0.001

MMP1

12.70

0.99

13.92

0.89

52.15

<0.001

<0.001

Cluster 7

IL-17A

1.69

0.27

1.89

0.55

8.52

0.004

0.013

IL-17C

2.74

0.66

3.08

1.05

4.88

0.029

0.039

IL-10

3.14

0.41

3.35

0.43

7.67

0.007

0.013

CCL20

6.91

0.86

7.20

1.07

3.63

0.059

0.059

  1. Protein levels are presented as untransformed, normalized log2 scaled protein expression (NPX) values. Cluster 6 shows the highest difference between high and low inflammatory potential groups. Bold values indicate significant p values.
  2. 1Post-hoc ANOVA.
  3. 2Benjamini & Hochberg correction for multiple testing within cluster.
  4. *Due to significant Levene’s test, the results for these proteins were also verified with a non-parametric test, with similar results.
Back to article page