Table 2 Performance measures for a range of dichotomous risk score cutoffs.

From: Development of an individualized risk calculator of treatment resistance in patients with first-episode psychosis (TRipCal) using automated machine learning: a 12-year follow-up study with clozapine prescription as a proxy indicator

Model

Threshold

Sensitivity

Specificity

PPV

NPV

NB

sNB

Baseline

0.05

0.99 ± 0.01

0.04 ± 0.05

0.14 ± 0.01

0.97 ± 0.04

0.09 ± 0.00

0.42 ± 0.01

0.10

0.84 ± 0.06

0.39 ± 0.06

0.18 ± 0.01

0.94 ± 0.02

0.06 ± 0.01

0.26 ± 0.03

0.15

0.54 ± 0.08

0.69 ± 0.04

0.22 ± 0.03

0.90 ± 0.01

0.03 ± 0.01

0.12 ± 0.04

0.20

0.33 ± 0.07

0.85 ± 0.03

0.26 ± 0.05

0.89 ± 0.01

0.01 ± 0.01

0.05 ± 0.04

0.25

0.18 ± 0.06

0.93 ± 0.03

0.29 ± 0.07

0.88 ± 0.01

0.00 ± 0.01

0.02 ± 0.03

0.30

0.08 ± 0.05

0.97 ± 0.02

0.31 ± 0.15

0.87 ± 0.00

0.00 ± 0.01

0.00 ± 0.02

0.35

0.03 ± 0.03

0.99 ± 0.01

0.36 ± 0.31

0.87 ± 0.00

0.00 ± 0.00

0.00 ± 0.02

0.40

0.01 ± 0.01

1.00 ± 0.01

0.31 ± 0.38

0.86 ± 0.00

0.00 ± 0.00

−0.01 ± 0.02

12-month

0.05

0.96 ± 0.04

0.15 ± 0.06

0.14 ± 0.01

0.97 ± 0.03

0.09 ± 0.00

0.39 ± 0.02

0.10

0.78 ± 0.08

0.49 ± 0.04

0.19 ± 0.01

0.94 ± 0.02

0.05 ± 0.01

0.24 ± 0.04

0.15

0.55 ± 0.08

0.72 ± 0.03

0.23 ± 0.03

0.92 ± 0.01

0.03 ± 0.01

0.13 ± 0.05

0.20

0.38 ± 0.06

0.85 ± 0.03

0.28 ± 0.05

0.90 ± 0.01

0.02 ± 0.01

0.08 ± 0.05

0.25

0.24 ± 0.06

0.93 ± 0.02

0.34 ± 0.08

0.89 ± 0.01

0.01 ± 0.01

0.04 ± 0.04

0.30

0.15 ± 0.05

0.96 ± 0.01

0.40 ± 0.12

0.88 ± 0.01

0.01 ± 0.01

0.03 ± 0.03

0.35

0.09 ± 0.04

0.98 ± 0.01

0.45 ± 0.18

0.88 ± 0.00

0.00 ± 0.01

0.01 ± 0.02

0.40

0.05 ± 0.03

0.99 ± 0.01

0.50 ± 0.27

0.88 ± 0.00

0.00 ± 0.00

0.01 ± 0.02

24-month

0.05

0.97 ± 0.03

0.23 ± 0.05

0.15 ± 0.01

0.98 ± 0.02

0.09 ± 0.00

0.39 ± 0.02

0.10

0.79 ± 0.07

0.57 ± 0.03

0.21 ± 0.01

0.95 ± 0.01

0.06 ± 0.01

0.26 ± 0.03

0.15

0.56 ± 0.07

0.77 ± 0.03

0.26 ± 0.03

0.93 ± 0.01

0.03 ± 0.01

0.16 ± 0.04

0.20

0.40 ± 0.06

0.87 ± 0.02

0.31 ± 0.04

0.91 ± 0.01

0.02 ± 0.01

0.10 ± 0.04

0.25

0.29 ± 0.06

0.92 ± 0.02

0.35 ± 0.07

0.90 ± 0.01

0.01 ± 0.01

0.06 ± 0.04

0.30

0.20 ± 0.05

0.95 ± 0.02

0.38 ± 0.09

0.89 ± 0.01

0.01 ± 0.01

0.03 ± 0.04

0.35

0.14 ± 0.04

0.97 ± 0.01

0.42 ± 0.14

0.89 ± 0.01

0.00 ± 0.01

0.01 ± 0.04

0.40

0.09 ± 0.04

0.98 ± 0.01

0.45 ± 0.17

0.88 ± 0.00

0.00 ± 0.01

0.00 ± 0.03

36-month

0.05

0.96 ± 0.03

0.32 ± 0.05

0.15 ± 0.01

0.98 ± 0.01

0.08 ± 0.00

0.35 ± 0.01

0.10

0.74 ± 0.08

0.64 ± 0.03

0.21 ± 0.02

0.95 ± 0.01

0.05 ± 0.01

0.22 ± 0.03

0.15

0.57 ± 0.07

0.81 ± 0.03

0.28 ± 0.03

0.94 ± 0.01

0.04 ± 0.01

0.16 ± 0.04

0.20

0.42 ± 0.08

0.89 ± 0.02

0.33 ± 0.05

0.92 ± 0.01

0.02 ± 0.01

0.11 ± 0.04

0.25

0.31 ± 0.07

0.93 ± 0.02

0.37 ± 0.07

0.91 ± 0.01

0.02 ± 0.01

0.07 ± 0.04

0.30

0.23 ± 0.06

0.96 ± 0.01

0.41 ± 0.09

0.91 ± 0.01

0.01 ± 0.01

0.04 ± 0.04

0.35

0.16 ± 0.06

0.97 ± 0.01

0.44 ± 0.11

0.90 ± 0.01

0.01 ± 0.01

0.02 ± 0.03

0.40

0.10 ± 0.05

0.98 ± 0.01

0.42 ± 0.17

0.89 ± 0.01

0.00 ± 0.01

0.01 ± 0.03