Table 1 Univariable MR results of sleep duration, sleep chronotype and insomnia on lifespan.
From: Shared genetic architecture and causal relationship between sleep behaviors and lifespan
MR Method | Number of IVs | F | β (95%CI) | P |
|---|---|---|---|---|
Short sleep duration on lifespan | ||||
 IVW | 22 | 38 | –0.60 (–0.95 to –0.26) | 5.78E–04 |
 Weighted median |  |  | –0.49 (–0.90 to –0.07) | 0.02 |
 MR-Egger |  |  | –0.61 (–1.94 to 0.73) | 0.38 |
 Weighted mode |  |  | –0.43 (–1.15 to 0.29) | 0.25 |
 MR.RAPS |  |  | –0.59 (–0.96 to –0.22) | 1.79E–03 |
Long sleep duration on lifespan | ||||
 IVW | 5 | 39 | 0.24 (–0.52 to 1.00) | 0.54 |
 Weighted median |  |  | 0.30 (–0.68 to 1.28) | 0.54 |
 MR-Egger |  |  | 1.34 (–3.71 to 1.02) | 0.35 |
 Weighted mode |  |  | 0.69 (–0.85 to 2.23) | 0.43 |
 MR.RAPS |  |  | 0.25 (–0.55 to 1.05) | 0.55 |
Sleep chronotype on lifespan | ||||
 IVW | 113 | 45 | 0.06 (–0.06 to 0.19) | 0.34 |
 Weighted median |  |  | 0.10 (–0.07 to 0.26) | 0.24 |
 MR-Egger |  |  | 0.15 (–0.26 to 0.56) | 0.47 |
 Weighted mode |  |  | 0.22 (–0.15 to 0.59) | 0.25 |
 MR.RAPS |  |  | 0.07 (–0.06 to 0.20) | 0.32 |
Insomnia on lifespan | ||||
 IVW | 11 | 43 | –0.01 (–0.10 to 0.08) | 0.83 |
 Weighted median |  |  | 0.03 (–0.08 to 0.13) | 0.62 |
 MR-Egger |  |  | 0.09 (–0.18 to 0.37) | 0.52 |
 Weighted mode |  |  | –0.06 (–0.09 to 0.21) | 0.46 |
 MR.RAPS |  |  | 0.0008 (–0.09 to 0.09) | 0.99 |
