Fig. 1: Experimental timeline.
From: µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice
At least 5 days following intracerebroventricular cannula implantation, mice were tested on the elevated zero maze. Before testing, mice were pretreated with vehicle (VEH) or an opioid antagonist: naloxone (NLX), CTAP, or norbinaltorphimine (norBNI) and treated with vehicle (VEH) or oxytocin (OXT). At least 7 days after the elevated zero maze tests, mice previously exposed to vehicle or naloxone and vehicle or oxytocin were then tested on the tail suspension test. On the day of the experiment, mice were pretreated and treated with the same drug combination.
