Fig. 1: Compositional variation in human gut CAZymes.

a, b The overall characteristics of CAZymes were displayed by Pcoa (bray-curtis distance), internal differences were analyzed with permanova test (permutations = 999, Bonferroni p = 0.002). Also, the distance of first and second principal component distance was showed by boxplots (Mann–Whitney U-test, p = 0.004). c Difference of 6 gut CAZymes diversity index between MDD and HC. d 83 discriminated CAZymes were identified between two groups (Mann–Whitney U-test). e The fold change of CAZymes related to plant and animal carbohydrate utilization, plant carbohydrate utilization and mucin glycan and animal to plant carbohydrate utilization in the MDD and HC. The boxplots displayed the respective distributions of three types of CAZymes in metagenome data (Mann–Whitney U-test, two-sided). Box-Whisker plot, box = 25–75th percentiles, whiskers = 5–95th percentiles, horizontal line in box = median.